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Irritable Bowel Syndrome
(Functional Colitis; IBS; Intestinal Neurosis; Irritable Colon; Laxative Colitis; Mucous Colitis; Nervous Indigestion; Spastic Colon)
Definition
Causes
Risk Factors
- Sex: female
- Family members with IBS
- Age: typically begins in young adulthood
- Stress
- Generalized anxiety disorder (associated with IBS)
- Abuse (may be associated with IBS)
Symptoms
- Abdominal cramps
- Gas and bloating
- Pain that resolves with a bowel movement
- Loose stools
- Diarrhea
- Constipation
- Alternating diarrhea and constipation
- Urge to move bowels again immediately following a bowel movement
- Mucus in the stool
- Stress
- Menstrual periods
- Large meals or fatty foods
- Excess gas
Diagnosis
- Analysis of a stool sample to check for blood or evidence of inflammation
- Blood tests
- Barium enema—injection of fluid into the rectum to make the colon show up on an x-ray, allows the doctor to see abnormal spots in the colon
- Flexible sigmoidoscopy—a thin, lighted tube inserted into the rectum to examine the rectum and the lower colon
- Colonoscopy—a thin, lighted tube inserted through the rectum and into the colon to examine the lining of the entire colon
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Treatment
Diet
- Keep a food diary of what you eat and how your body responds. Share this with your doctor. You may have a food allergy.
- Make gradual changes to your diet. Record the results.
- Avoid foods that have caused problems in the past. A dietitian can help you substitute foods.
- Avoid foods and drinks that may cause symptoms:
-
Eat foods that may reduce the chance of spasm, such as:
- Fruits and vegetables
- Whole grains and other high-fiber foods (more fiber may increase gas and bloating until your body adjusts).
- Eat smaller meals more often or smaller portions.
- Eat slowly and try not to swallow air.
- Drink plenty of water. This will help to reduce constipation.
Exercise
Stress Management
- Relaxation
- Biofeedback
- Counseling
Education
Medication
- Antispasmodic agent (such as dicyclomine, alverine citrate)
- Antibiotics (rifaximin [Xifaxan])
- High-fiber bulking agent (psyllium )
- Antiflatulent (simethicone )
- Antidiarrheal agent (loperamide )
- Low-dose antidepressant
- Pain reliever (acetaminophen)—may help with crampy abdominal pain
- Serotonin receptor agonists and antagonists (also called 5-HT3 antagonists)—may be helpful for treating diarrhea, as well as treating other IBS symptoms, like abdominal pain in women (alosetron)
- Probiotics ("friendly" bacteria)—may be helpful, but talk to your doctor before taking
- Peppermint oil
RESOURCES
American College of Gastroenterology http://gi.org
American Gastroenterological Association http://www.gastro.org
Irritable Bowel Syndrome Association http://www.ibsgroup.org
CANADIAN RESOURCES
Health Canada http://www.hc-sc.gc.ca
Irritable Bowel Syndrome Association http://www.ibsgroup.org
References
Acidophilus and other probiotics. EBSCO Natural and Alternative Treatments website. Available at: http://www.ebscohost.com/healthLibrary/. Updated June 2008. Accessed July 15, 2008.
Conn HF, Rakel RE. Conn's Current Therapy. Philadelphia, PA: WB Saunders Co; 2001.
Drossman DA. Treatment for bacterial overgrowth in the irritable bowel syndrome. Ann Intern Med . 2006;145:626-628.
Griffith HW. Griffith's 5-Minute Clinical Consult. Baltimore, MD: Lippincott Williams Wilkins; 1999.
Halvorson HA, Schlett CD, Riddle MS. Postinfectious irritable bowel syndrome—a meta-analysis. Am J Gastroenterol. 2006;101:1894-1899.
Irritable bowel syndrome. American Society of Colon and Rectal Surgeons website. Available at: http://www.fascrs.org/. Update October 2007. Accessed July 15, 2008.
Irritable bowel syndrome. EBSCO DynaMed website. Available at: https://dynamed.ebscohost.com/about/about-us. Updated December 2008. Accessed January 6, 2009.
Irritable bowel syndrome (IBS). EBSCO Health Library website. Available at: http://www.ebscohost.com/healthLibrary/. Updated July 2008. Accessed July 7, 2008.
Irritable bowel syndrome. National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: http://www.niddk.nih.gov/ Update September 2007. Accessed July 15, 2008.
Murch S. Allergy and intestinal dysmotility—evidence of genuine causal linkage? Curr Opin Gastroenterol . 2006;22:664-668.
Rubin G, De Wit N, Meineche-Schmidt V, Seifert B, Hall N, Hungin P. The diagnosis of IBS in primary care: consensus development using nominal group technique. Family Practitioner. 2006;23:687-692.
Sleisenger MH, Fordtran JS, Feldman M, Scharschmidt B. Sleisenger Fordtran's Gastrointestinal and Liver Disease. 6th ed. Philadelphia, PA: WB Saunders Co; 1998.
Talley NJ, Boyce PM, Jones M. Is the association between irritable bowel syndrome and abuse explained by neuroticism? A population based study. Gut.1998;42: 47-53.
Yan F, Polk DB. Probiotics as functional food in the treatment of diarrhea. Current Opinion in Clinical Nutrition and Metabolic Care. 2006;9:717-721.
9/26/2006 DynaMed's Systematic Literature Surveillance https://dynamed.ebscohost.com/about/about-us : Mueller-Lissner S, Tytgat GN, Paulo LG, et al. Placebo-and paracetamol-controlled study on the efficacy and tolerability of hyoscine butylbromide in the treatment of patients with recurrent crampy abdominal pain. Alimentary Pharmacology and Therapeutics . 2006;23:1741-1748.
4/10/2007 DynaMed's Systematic Literature Surveillance https://dynamed.ebscohost.com/about/about-us : US Food and Drug Administration. FDA announces discontinued marketing of GI drug, Zelnorm, for safety reasons [press release]. March 30, 2007. US Food and Drug Administration website. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2007/ucm108879.htm.
1/6/2009 DynaMed's Systematic Literature Surveillance https://dynamed.ebscohost.com/about/about-us : Ford AC, Talley NJ, Spiegel BM, et al. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. BMJ . 2008;337:a2313.
10/9/2009 DynaMed Systematic Literature Surveillance https://dynamed.ebscohost.com/about/about-us : Lee S, Wu J, Ma YL, Tsang A, Guo WJ, Sung J. Irritable bowel syndrome is strongly associated with generalized anxiety disorder: a community study. Aliment Pharmacol Ther. 2009;30(6):643.
11/4/2009 DynaMed Systematic Literature Surveillance https://dynamed.ebscohost.com/about/about-us : Ford AC, Brandt LJ, Young C, Chey WD, Foxx-Orenstein AE, Moayyedi P. Efficacy of 5-HT3 antagonists and 5-HT4 agonists in irritable bowel syndrome: systematic review and meta-analysis. Am J Gastroenterol. 2009;104(7):1831-1843.
1/11/2010 DynaMed's Systematic Literature Surveillance https://dynamed.ebscohost.com/about/about-us : Wittmann T, Paradowski L, Ducrotté P, Bueno L, Andro Delestrain MC. Clinical trial: efficacy of alverine citrate/simeticone combination on abdominal pain/discomfort in irritable bowel syndrome: results of a randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2009 Dec 10. [Epub ahead of print]
7/16/2010 DynaMed's Systematic Literature Surveillance https://dynamed.ebscohost.com/about/about-us : Dorn SD. Systematic review: self-management support interventions for irritable bowel syndrome. Aliment Pharmacol Ther. 2010 May 22. [Epub ahead of print]
1/14/2011 DynaMed's Systematic Literature Surveillance https://dynamed.ebscohost.com/about/about-us : Pimentel M, Lembo A, Chey WD, et al. Rifaximin therapy for patients with irritable bowel syndrome without constipation. N Engl J Med. 2011;364(1):22-32.
4/22/2011 DynaMed's Systematic Literature Surveillance https://dynamed.ebscohost.com/about/about-us : Johannesson E, Simrén M, Strid H, Bajor A, Sadik R. Physical activity improves symptoms in irritable bowel syndrome: a randomized controlled trial. Am J Gastroenterol. 2011 Jan 4. [Epub ahead of print]